| 1. Round | 23/01/2022 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 0:1 | ||||
| 4. Round | 14/02/2022 | Diriangén FC | - | Club Deportivo Ocotal | 2:0 | ||||
| 6. Round | 28/02/2022 | Club Deportivo Ocotal | - | Juventus Managua | 0:1 | ||||
| 7. Round | 03/03/2022 | Managua FC | - | Club Deportivo Ocotal | 1:1 | ||||
| 8. Round | 06/03/2022 | UNAN Managua | - | Club Deportivo Ocotal | 2:1 | ||||
| 9. Round | 11/03/2022 | Real Estelí FC | - | Club Deportivo Ocotal | 4:1 |  |
|||
| 10. Round | 13/03/2022 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 0:0 | ||||
| 11. Round | 18/03/2022 | CD Walter Ferretti | - | Club Deportivo Ocotal | 4:1 | ||||
| 13. Round | 07/04/2022 | Club Deportivo Ocotal | - | Diriangén FC | 1:0 | ||||
| 17. Round | 28/04/2022 | Club Deportivo Ocotal | - | UNAN Managua | 0:0 | |
Nicaragua