| 1. Round | 17/07/2021 | Gaz Metan Mediaş | - | CS Mioveni | 1:0 | ||||
| 4. Round | 08/08/2021 | FCSB | - | Gaz Metan Mediaş | 2:1 | ||||
| 6. Round | 21/08/2021 | CS Universitatea Craiova | - | Gaz Metan Mediaş | 1:0 |  |
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| 7. Round | 30/08/2021 | Gaz Metan Mediaş | - | UTA Arad | 0:1 | ||||
| 8. Round | 12/09/2021 | Gaz Metan Mediaş | - | FC Voluntari | 1:2 | ||||
| 9. Round | 17/09/2021 | Rapid Bucureşti | - | Gaz Metan Mediaş | 1:2 | ||||
| 10. Round | 27/09/2021 | Gaz Metan Mediaş | - | Sepsi OSK | 0:0 | ||||
| 11. Round | 03/10/2021 | CFR Cluj | - | Gaz Metan Mediaş | 2:1 | ||||
| 15. Round | 05/11/2021 | Chindia Târgoviște | - | Gaz Metan Mediaş | 0:1 | |
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| 27. Round | 18/02/2022 | Dinamo Bucureşti | - | Gaz Metan Mediaş | 4:0 | ||||
| 28. Round | 26/02/2022 | Gaz Metan Mediaş | - | FC Universitatea Craiova | 0:3 | ||||
| 29. Round | 02/03/2022 | Academica Clinceni | - | Gaz Metan Mediaş | 2:0 | ||||
| 30. Round | 06/03/2022 | Gaz Metan Mediaş | - | Chindia Târgoviște | 0:4 |
Romania