| 1. Round | 02/08/2021 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 1:1 |  |
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| 2. Round | 09/08/2021 | ART Municipal Jalapa | - | Managua FC | 1:1 | ||||
| 5. Round | 30/08/2021 | Real Estelí FC | - | ART Municipal Jalapa | 2:0 | ||||
| 6. Round | 03/09/2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 | |
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| 7. Round | 12/09/2021 | Real Madriz | - | ART Municipal Jalapa | 1:0 | ||||
| 8. Round | 20/09/2021 | Juventus Managua | - | ART Municipal Jalapa | 3:1 | ||||
| 9. Round | 27/09/2021 | ART Municipal Jalapa | - | Diriangén FC | 2:1 |  |
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| 10. Round | 03/10/2021 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 0:0 |  |
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| 13. Round | 21/10/2021 | CD Walter Ferretti | - | ART Municipal Jalapa | 5:0 | ||||
| 14. Round | 24/10/2021 | ART Municipal Jalapa | - | Real Estelí FC | 2:1 | |
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| 16. Round | 04/11/2021 | H&H Export Sébaco | - | ART Municipal Jalapa | 3:0 | ||||
| 17. Round | 19/11/2021 | ART Municipal Jalapa | - | Juventus Managua | 1:1 | ||||
| 18. Round | 22/11/2021 | Diriangén FC | - | ART Municipal Jalapa | 5:0 |
Colombia