| 1. Round | 07/01/2012 | Monarcas Morelia | - | Club Tijuana | 1:1 | ||||
| 2. Round | 15/01/2012 | Club Tijuana | - | CF Monterrey | 1:0 | ||||
| 3. Round | 22/01/2012 | Deportivo Guadalajara | - | Club Tijuana | 0:2 |  |
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| 4. Round | 29/01/2012 | Club Tijuana | - | Santos Laguna | 1:3 | |
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| 5. Round | 05/02/2012 | Puebla FC | - | Club Tijuana | 1:1 |  |
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| 6. Round | 12/02/2012 | Club Tijuana | - | Cruz Azul | 0:0 | ||||
| 7. Round | 18/02/2012 | Gallos Blancos (old) | - | Club Tijuana | 0:2 | |
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| 8. Round | 26/02/2012 | Club Tijuana | - | Deportivo Toluca | 1:1 | |
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| 9. Round | 03/03/2012 | Estudiantes Tecos | - | Club Tijuana | 0:2 | |
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| 10. Round | 10/03/2012 | Club Tijuana | - | CF América | 1:1 | |
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| 11. Round | 18/03/2012 | UANL Tigres | - | Club Tijuana | 1:0 | |
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| 13. Round | 31/03/2012 | CF Pachuca | - | Club Tijuana | 1:0 | ||||
| 14. Round | 08/04/2012 | Club Tijuana | - | Atlante | 2:1 | ||||
| 15. Round | 14/04/2012 | Jaguares Chiapas | - | Club Tijuana | 0:0 | ||||
| 16. Round | 21/04/2012 | Club San Luis | - | Club Tijuana | 0:1 | |
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| 17. Round | 29/04/2012 | Club Tijuana | - | Pumas UNAM | 1:1 | |
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Colombia