| 1. Round | 21/07/2012 | Club Tijuana | - | Puebla FC | 2:0 | ||||
| 2. Round | 28/07/2012 | Club León | - | Club Tijuana | 4:0 | ||||
| 3. Round | 04/08/2012 | Club Tijuana | - | Pumas UNAM | 1:0 | ||||
| 4. Round | 12/08/2012 | CF Pachuca | - | Club Tijuana | 2:2 | ||||
| 6. Round | 25/08/2012 | CF América | - | Club Tijuana | 0:1 | ||||
| 7. Round | 01/09/2012 | Club Tijuana | - | Jaguares Chiapas | 2:0 |  |
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| 8. Round | 17/09/2012 | Atlante | - | Club Tijuana | 1:2 | |
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| 9. Round | 23/09/2012 | Club Tijuana | - | Atlas Guadalajara | 1:1 | |
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| 10. Round | 29/09/2012 | Gallos Blancos (old) | - | Club Tijuana | 0:1 | ||||
| 11. Round | 04/10/2012 | CF Monterrey | - | Club Tijuana | 1:1 | ||||
| 12. Round | 08/10/2012 | Club Tijuana | - | Deportivo Toluca | 1:0 | |
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| 13. Round | 14/10/2012 | Santos Laguna | - | Club Tijuana | 2:2 | |
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| 14. Round | 20/10/2012 | Club Tijuana | - | Cruz Azul | 2:2 | |
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| 15. Round | 28/10/2012 | Monarcas Morelia | - | Club Tijuana | 1:1 | |
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| 16. Round | 04/11/2012 | Club Tijuana | - | Club San Luis | 0:0 | ||||
| 17. Round | 11/11/2012 | Deportivo Guadalajara | - | Club Tijuana | 0:2 | |
Colombia