| 1. Round | 01/08/2021 | Alianza | - | Municipal Limeño | 4:1 |  |
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| 2. Round | 08/08/2021 | Platense Zacatecoluca | - | Alianza | 2:2 | ||||
| 3. Round | 11/08/2021 | AD Chalatenango | - | Alianza | 2:1 | |
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| 4. Round | 15/08/2021 | Alianza | - | Luis Ángel Firpo | 2:2 | ||||
| 6. Round | 26/08/2021 | Alianza | - | FAS | 1:0 | ||||
| 9. Round | 16/09/2021 | Santa Tecla FC | - | Alianza | 0:4 | |
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| 10. Round | 19/09/2021 | Alianza | - | CD Águila | 2:1 | ||||
| 11. Round | 25/09/2021 | Jocoro FC | - | Alianza | 3:3 | |
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| 12. Round | 02/10/2021 | Municipal Limeño | - | Alianza | 0:3 | ||||
| 13. Round | 17/10/2021 | Alianza | - | Platense Zacatecoluca | 4:0 | |
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| 14. Round | 21/10/2021 | Alianza | - | AD Chalatenango | 1:0 | ||||
| 15. Round | 24/10/2021 | Luis Ángel Firpo | - | Alianza | 2:1 | ||||
| 16. Round | 30/10/2021 | Once Municipal | - | Alianza | 2:3 | |
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| 17. Round | 02/11/2021 | FAS | - | Alianza | 0:1 | |
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| 18. Round | 06/11/2021 | Alianza | - | Isidro Metapán | 1:0 | ||||
| 19. Round | 13/11/2021 | Atlético Marte | - | Alianza | 2:1 | ||||
| 20. Round | 18/11/2021 | Alianza | - | Santa Tecla FC | 5:0 | |
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| 21. Round | 21/11/2021 | CD Águila | - | Alianza | 0:1 | |
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| 22. Round | 27/11/2021 | Alianza | - | Jocoro FC | 2:0 | |
Colombia