| 1. Round | 07/08/2021 | Northampton Town | - | Port Vale FC | 1:0 |  |
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| 4. Round | 21/08/2021 | Northampton Town | - | Rochdale AFC | 1:3 | ||||
| 5. Round | 28/08/2021 | Crawley Town | - | Northampton Town | 0:0 | |
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| 6. Round | 04/09/2021 | Northampton Town | - | Scunthorpe United | 2:0 | ||||
| 7. Round | 11/09/2021 | Forest Green Rovers | - | Northampton Town | 1:0 | ||||
| 3. Round | 14/09/2021 | Newport County | - | Northampton Town | 0:1 | ||||
| 8. Round | 18/09/2021 | Northampton Town | - | Swindon Town | 1:1 | ||||
| 9. Round | 25/09/2021 | Salford City | - | Northampton Town | 2:2 | ||||
| 11. Round | 09/10/2021 | Hartlepool United | - | Northampton Town | 2:1 | ||||
| 13. Round | 19/10/2021 | Northampton Town | - | Stevenage FC | 3:0 | ||||
| 16. Round | 13/11/2021 | Bristol Rovers | - | Northampton Town | 2:1 | ||||
| 18. Round | 23/11/2021 | Northampton Town | - | Oldham Athletic | 2:1 | ||||
| 21. Round | 11/12/2021 | Harrogate Town | - | Northampton Town | 1:2 | ||||
| 25. Round | 01/01/2022 | Swindon Town | - | Northampton Town | 5:2 | ||||
| 26. Round | 08/01/2022 | Northampton Town | - | Crawley Town | 0:1 | ||||
| 27. Round | 15/01/2022 | Northampton Town | - | Forest Green Rovers | 1:1 | ||||
| 28. Round | 22/01/2022 | Sutton United | - | Northampton Town | 0:0 |
Ireland