| 3. Round | 04/09/2022 | Gżira United | - | Marsaxlokk FC | 0:0 |  |
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| 1. Round | 07/09/2022 | Hamrun Spartans | - | Marsaxlokk FC | 1:0 | ||||
| 4. Round | 11/09/2022 | Marsaxlokk FC | - | Balzan FC | 1:2 | |
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| 5. Round | 01/10/2022 | Żebbuġ Rangers | - | Marsaxlokk FC | 0:3 | ||||
| 6. Round | 08/10/2022 | Marsaxlokk FC | - | St. Luċija FC | 2:2 | ||||
| 7. Round | 17/10/2022 | Gudja United | - | Marsaxlokk FC | 1:2 | ||||
| 8. Round | 23/10/2022 | Marsaxlokk FC | - | Birkirkara FC | 1:0 | ||||
| 9. Round | 30/10/2022 | Marsaxlokk FC | - | Hibernians FC | 1:1 | ||||
| 12. Round | 03/12/2022 | Floriana FC | - | Marsaxlokk FC | 1:1 | ||||
| 13. Round | 11/12/2022 | Marsaxlokk FC | - | Valletta FC | 1:2 | ||||
| 14. Round | 16/12/2022 | Marsaxlokk FC | - | Hamrun Spartans | 0:1 | |
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| 15. Round | 08/01/2023 | Mosta FC | - | Marsaxlokk FC | 2:1 | |
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| 18. Round | 05/02/2023 | Marsaxlokk FC | - | Żebbuġ Rangers | 1:1 |  |
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| 22. Round | 11/03/2023 | Hibernians FC | - | Marsaxlokk FC | 1:3 | ||||
| 23. Round | 02/04/2023 | Marsaxlokk FC | - | Pietá Hotspurs | 1:2 | ||||
| 24. Round | 08/04/2023 | Sirens FC | - | Marsaxlokk FC | 3:2 | ||||
| 25. Round | 14/04/2023 | Marsaxlokk FC | - | Floriana FC | 1:5 | ||||
| 26. Round | 20/04/2023 | Valletta FC | - | Marsaxlokk FC | 1:1 |
Nigeria