| 1. Round | 23/07/2023 | UMECIT | - | San Francisco FC | 0:1 | ||||
| 2. Round | 29/07/2023 | San Francisco FC | - | Independiente de La Chorrera | 0:2 | ||||
| 3. Round | 06/08/2023 | Herrera FC | - | San Francisco FC | 0:0 | ||||
| 4. Round | 14/08/2023 | San Francisco FC | - | Atlético Chiriquí | 0:0 | ||||
| 5. Round | 19/08/2023 | UD Universitario | - | San Francisco FC | 1:0 | ||||
| 6. Round | 28/08/2023 | Sporting San Miguelito | - | San Francisco FC | 2:0 | ||||
| 7. Round | 03/09/2023 | San Francisco FC | - | Alianza | 2:2 | ||||
| 8. Round | 10/09/2023 | Plaza Amador | - | San Francisco FC | 0:1 |  |
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| 9. Round | 16/09/2023 | San Francisco FC | - | Tauro FC | 0:0 | ||||
| 10. Round | 24/09/2023 | San Francisco FC | - | Árabe Unido | 0:2 | ||||
| 11. Round | 01/10/2023 | Potros del Este | - | San Francisco FC | 0:2 | ||||
| 13. Round | 15/10/2023 | Independiente de La Chorrera | - | San Francisco FC | 2:0 | |
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| 14. Round | 20/10/2023 | San Francisco FC | - | Herrera FC | 3:1 | ||||
| 15. Round | 23/10/2023 | Atlético Chiriquí | - | San Francisco FC | 0:6 | ||||
| 16. Round | 01/11/2023 | San Francisco FC | - | UD Universitario | 2:1 |
Panama