| 1. Round | 21/07/2024 | UMECIT | - | San Francisco FC | 0:2 |  |
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| 2. Round | 27/07/2024 | San Francisco FC | - | Independiente de La Chorrera | 1:2 | ||||
| 3. Round | 03/08/2024 | San Francisco FC | - | Veraguas United | 1:2 | ||||
| 4. Round | 11/08/2024 | Herrera FC | - | San Francisco FC | 3:3 | |
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| 5. Round | 20/08/2024 | San Francisco FC | - | UD Universitario | 1:2 | ||||
| 6. Round | 25/08/2024 | San Francisco FC | - | Árabe Unido | 0:0 |  |
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| 7. Round | 02/09/2024 | Tauro FC | - | San Francisco FC | 1:1 | |
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| 8. Round | 07/09/2024 | San Francisco FC | - | Sporting San Miguelito | 0:1 | |
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| 10. Round | 21/09/2024 | Alianza | - | San Francisco FC | 3:1 | ||||
| 11. Round | 28/09/2024 | San Francisco FC | - | Potros del Este | 1:1 | ||||
| 12. Round | 06/10/2024 | Veraguas United | - | San Francisco FC | 1:1 | ||||
| 13. Round | 13/10/2024 | UD Universitario | - | San Francisco FC | 1:0 | ||||
| 14. Round | 19/10/2024 | Independiente de La Chorrera | - | San Francisco FC | 1:0 | ||||
| 15. Round | 26/10/2024 | San Francisco FC | - | Herrera FC | 1:0 | ||||
| 16. Round | 01/11/2024 | San Francisco FC | - | UMECIT | 0:2 |
Panama