| 14. Round | 18/09/2021 | 1. FC Schweinfurt 05 | - | SV Schalding-Heining | 6:0 | ||||
| 19. Round | 23/10/2021 | 1. FC Schweinfurt 05 | - | Viktoria Aschaffenburg | 2:1 | ||||
| 27. Round | 05/03/2022 | SV Heimstetten | - | 1. FC Schweinfurt 05 | 2:2 | ||||
| 28. Round | 12/03/2022 | 1. FC Schweinfurt 05 | - | SC Eltersdorf | 4:2 | ||||
| 29. Round | 19/03/2022 | VfB Eichstätt | - | 1. FC Schweinfurt 05 | 0:0 | ||||
| 30. Round | 26/03/2022 | 1. FC Schweinfurt 05 | - | FC Memmingen | 1:0 | ||||
| 31. Round | 04/04/2022 | Bayern München II | - | 1. FC Schweinfurt 05 | 5:1 |  |
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| 32. Round | 09/04/2022 | 1. FC Schweinfurt 05 | - | FC Pipinsried | 3:0 |  |
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| 21. Round | 26/04/2022 | TSV 1896 Rain | - | 1. FC Schweinfurt 05 | 2:1 | ||||
| 35. Round | 30/04/2022 | TSV 1860 Rosenheim | - | 1. FC Schweinfurt 05 | 2:2 | ||||
| 36. Round | 07/05/2022 | 1. FC Schweinfurt 05 | - | SpVgg Bayreuth | 1:5 | ||||
| 37. Round | 14/05/2022 | 1. FC Schweinfurt 05 | - | FV Illertissen | 1:2 | ||||
| 38. Round | 17/05/2022 | Viktoria Aschaffenburg | - | 1. FC Schweinfurt 05 | 3:2 |
Germany