| 1. Round | 19/07/2021 | Deportes Tolima | - | Deportivo Pereira | 1:0 | ||||
| 2. Round | 25/07/2021 | Atlético Nacional | - | Deportes Tolima | 1:0 | ||||
| 3. Round | 31/07/2021 | Deportes Tolima | - | Alianza Petrolera | 1:1 | ||||
| 4. Round | 09/08/2021 | Atlético Junior | - | Deportes Tolima | 0:0 |  |
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| 5. Round | 14/08/2021 | Deportes Tolima | - | Deportivo Pasto | 1:0 | |
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| 11. Round | 26/09/2021 | Patriotas FC | - | Deportes Tolima | 0:0 |  |
Colombia