1. Round | 19/01/2022 | Lobos UPNFM | - | Vida | 3:0 dec. | ||||
2. Round | 23/01/2022 | Honduras Progreso | - | Lobos UPNFM | 1:2 | ||||
4. Round | 10/02/2022 | Lobos UPNFM | - | Platense | 1:2 | ||||
7. Round | 26/02/2022 | Lobos UPNFM | - | Olimpia | 0:3 | ||||
8. Round | 03/03/2022 | Real España | - | Lobos UPNFM | 1:0 | ||||
9. Round | 06/03/2022 | Marathón | - | Lobos UPNFM | 4:1 | ||||
11. Round | 19/03/2022 | Lobos UPNFM | - | Honduras Progreso | 2:2 | ||||
14. Round | 10/04/2022 | Motagua | - | Lobos UPNFM | 2:0 | ||||
15. Round | 14/04/2022 | Lobos UPNFM | - | Real España | 0:2 | ||||
17. Round | 25/04/2022 | Olimpia | - | Lobos UPNFM | 0:1 | ||||
18. Round | 01/05/2022 | Lobos UPNFM | - | Marathón | 1:2 |