| 2. Round | 23/07/2021 | Mannucci | - | Deportivo Municipal | 1:2 |  |
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| 3. Round | 30/07/2021 | Deportivo Municipal | - | Sporting Cristal | 1:1 | ||||
| 4. Round | 03/08/2021 | Cienciano | - | Deportivo Municipal | 2:3 | ||||
| 10. Round | 11/09/2021 | Alianza Universidad | - | Deportivo Municipal | 0:3 | ||||
| 11. Round | 19/09/2021 | Universitario de Deportes | - | Deportivo Municipal | 0:2 | ||||
| 14. Round | 02/10/2021 | Deportivo Municipal | - | Deportivo Binacional | 1:2 | |
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| 15. Round | 18/10/2021 | Cusco FC | - | Deportivo Municipal | 3:5 | ||||
| 16. Round | 24/10/2021 | Deportivo Municipal | - | FBC Melgar | 1:3 | ||||
| 17. Round | 30/10/2021 | Alianza Atlético | - | Deportivo Municipal | 0:2 | |
Peru