| 1. Round | 17/02/2021 | Honduras Progreso | - | Marathón | 1:1 | ||||
| 2. Round | 21/02/2021 | Honduras Progreso | - | Vida | 0:0 | ||||
| 3. Round | 25/02/2021 | Real España | - | Honduras Progreso | 1:0 | ||||
| 4. Round | 28/02/2021 | Platense | - | Honduras Progreso | 0:4 |  |
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| 5. Round | 04/03/2021 | Honduras Progreso | - | Lobos UPNFM | 0:3 | |
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| 6. Round | 07/03/2021 | Marathón | - | Honduras Progreso | 1:1 | ||||
| 7. Round | 10/03/2021 | Vida | - | Honduras Progreso | 1:1 | |
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| 8. Round | 18/03/2021 | Honduras Progreso | - | Real España | 1:1 | |
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| 9. Round | 21/03/2021 | Honduras Progreso | - | Platense | 2:2 | |
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| 10. Round | 01/04/2021 | Lobos UPNFM | - | Honduras Progreso | 0:2 | |
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| 11. Round | 11/04/2021 | Motagua | - | Honduras Progreso | 5:2 | ||||
| 12. Round | 18/04/2021 | Honduras Progreso | - | Olimpia | 0:5 | ||||
| 13. Round | 21/04/2021 | Real Sociedad | - | Honduras Progreso | 3:1 | ||||
| 14. Round | 28/04/2021 | Honduras Progreso | - | Real de Minas | 5:2 | |
Argentina