| 1. Round | 31/07/2021 | CSD Municipal | - | Deportivo Guastatoya | 1:0 |  |
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| 2. Round | 07/08/2021 | Santa Lucía | - | CSD Municipal | 1:1 | ||||
| 3. Round | 11/08/2021 | CSD Municipal | - | Deportivo Malacateco | 4:0 | ||||
| 4. Round | 14/08/2021 | CSD Municipal | - | Iztapa | 2:2 | ||||
| 5. Round | 22/08/2021 | Xelaju MC | - | CSD Municipal | 0:0 | ||||
| 6. Round | 25/08/2021 | CSD Municipal | - | Sololá FC | 2:3 | ||||
| 10. Round | 18/09/2021 | CSD Municipal | - | Cobán Imperial | 2:1 | ||||
| 8. Round | 29/09/2021 | CSD Municipal | - | Achuapa | 1:0 | ||||
| 12. Round | 03/10/2021 | Deportivo Guastatoya | - | CSD Municipal | 1:0 | ||||
| 14. Round | 17/10/2021 | Deportivo Malacateco | - | CSD Municipal | 1:0 | ||||
| 16. Round | 27/10/2021 | CSD Municipal | - | Xelaju MC | 3:0 | ||||
| 17. Round | 01/11/2021 | Sololá FC | - | CSD Municipal | 1:4 | ||||
| 18. Round | 06/11/2021 | CSD Municipal | - | Nueva Concepción | 2:0 | ||||
| 19. Round | 14/11/2021 | Achuapa | - | CSD Municipal | 0:1 | ||||
| 20. Round | 20/11/2021 | CSD Municipal | - | Comunicaciones | 0:0 | ||||
| 21. Round | 28/11/2021 | Cobán Imperial | - | CSD Municipal | 0:1 | ||||
| 22. Round | 05/12/2021 | CSD Municipal | - | Antigua GFC | 1:0 |
Guatemala