| 1. Round | 16/01/2022 | Santa Lucía | - | CSD Municipal | 0:2 | ||||
| 2. Round | 22/01/2022 | CSD Municipal | - | Deportivo Guastatoya | 0:0 | ||||
| 3. Round | 30/01/2022 | Sololá FC | - | CSD Municipal | 0:3 | ||||
| 5. Round | 06/02/2022 | Deportivo Malacateco | - | CSD Municipal | 2:1 | ||||
| 6. Round | 09/02/2022 | CSD Municipal | - | Xelaju MC | 2:2 | ||||
| 8. Round | 19/02/2022 | CSD Municipal | - | Cobán Imperial | 3:2 | ||||
| 9. Round | 27/02/2022 | Iztapa | - | CSD Municipal | 2:1 | ||||
| 11. Round | 05/03/2022 | CSD Municipal | - | Achuapa | 0:1 | ||||
| 12. Round | 12/03/2022 | CSD Municipal | - | Santa Lucía | 2:1 | ||||
| 14. Round | 06/04/2022 | CSD Municipal | - | Sololá FC | 4:0 |  |
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| 16. Round | 09/04/2022 | CSD Municipal | - | Deportivo Malacateco | 2:0 | ||||
| 19. Round | 13/04/2022 | Cobán Imperial | - | CSD Municipal | 1:1 | ||||
| 17. Round | 17/04/2022 | Xelaju MC | - | CSD Municipal | 0:1 | ||||
| 22. Round | 08/05/2022 | Achuapa | - | CSD Municipal | 0:0 |
Guatemala