| 1. Round | 01/08/2021 | Luis Ángel Firpo | - | Jocoro FC | 1:1 | ||||
| 2. Round | 08/08/2021 | Municipal Limeño | - | Luis Ángel Firpo | 1:1 | ||||
| 3. Round | 11/08/2021 | Luis Ángel Firpo | - | Platense Zacatecoluca | 3:2 |  |
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| 4. Round | 15/08/2021 | Alianza | - | Luis Ángel Firpo | 2:2 | |
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| 6. Round | 25/08/2021 | Luis Ángel Firpo | - | Once Municipal | 2:2 | ||||
| 8. Round | 12/09/2021 | Luis Ángel Firpo | - | Isidro Metapán | 1:1 | ||||
| 9. Round | 15/09/2021 | Atlético Marte | - | Luis Ángel Firpo | 1:3 | ||||
| 10. Round | 19/09/2021 | Luis Ángel Firpo | - | Santa Tecla FC | 0:0 | ||||
| 12. Round | 02/10/2021 | Jocoro FC | - | Luis Ángel Firpo | 2:1 | ||||
| 15. Round | 24/10/2021 | Luis Ángel Firpo | - | Alianza | 2:1 | ||||
| 16. Round | 31/10/2021 | Luis Ángel Firpo | - | AD Chalatenango | 4:2 | ||||
| 17. Round | 02/11/2021 | Once Municipal | - | Luis Ángel Firpo | 1:0 | ||||
| 21. Round | 21/11/2021 | Santa Tecla FC | - | Luis Ángel Firpo | 2:2 | ||||
| 22. Round | 27/11/2021 | Luis Ángel Firpo | - | CD Águila | 1:0 |
El Salvador