| 1. Round | 11/08/2021 | Dinamo Kiev | - | FC Mynai | 2:0 |  |
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| 5. Round | 21/08/2021 | NK Veres | - | FC Mynai | 1:0 | ||||
| 7. Round | 12/09/2021 | FC Mynai | - | Chernomorets Odessa | 2:2 | ||||
| 9. Round | 26/09/2021 | FC Mynai | - | FK Lviv | 1:2 | ||||
| 10. Round | 03/10/2021 | Metalist 1925 Kharkiv | - | FC Mynai | 1:0 | ||||
| 12. Round | 24/10/2021 | Rukh Lviv | - | FC Mynai | 2:2 | ||||
| 15. Round | 21/11/2021 | FC Mynai | - | Inhulets Petrove | 2:2 | ||||
| 16. Round | 27/11/2021 | FC Mynai | - | Dinamo Kiev | 0:2 | ||||
| 17. Round | 05/12/2021 | FK Oleksandriya | - | FC Mynai | 3:0 | ||||
| 18. Round | 12/12/2021 | Kolos Kovalivka | - | FC Mynai | 2:1 |
Ukraine