1. Round | 07/02/2021 | Club Olimpia | - | Libertad | 0:1 | ||||
2. Round | 10/02/2021 | 12 de Octubre de Itauguá | - | Club Olimpia | 0:2 | ||||
3. Round | 14/02/2021 | Club Olimpia | - | Guaireña FC | 0:0 | ||||
5. Round | 28/02/2021 | Club Olimpia | - | Cerro Porteño | 2:0 | ||||
6. Round | 06/03/2021 | Sol de América | - | Club Olimpia | 0:2 | ||||
7. Round | 10/03/2021 | Club Olimpia | - | Club Nacional | 1:4 | ||||
12. Round | 16/04/2021 | Guaireña FC | - | Club Olimpia | 1:2 |