| 5. Round | 05/09/2021 | Independiente de La Chorrera | - | Atlético Chiriquí | 1:2 | ||||
| 11. Round | 16/10/2021 | Atlético Chiriquí | - | Sporting San Miguelito | 1:1 | ||||
| 12. Round | 23/10/2021 | San Francisco FC | - | Atlético Chiriquí | 1:0 | ||||
| 13. Round | 31/10/2021 | Atlético Chiriquí | - | Herrera FC | 0:0 | ||||
| 15. Round | 13/11/2021 | Veraguas Club Deportivo | - | Atlético Chiriquí | 0:2 |  |
Panama