| 2. Round | 13/02/2022 | UD Universitario | - | Atlético Chiriquí | 0:1 | ||||
| 3. Round | 20/02/2022 | Atlético Chiriquí | - | San Francisco FC | 2:1 | ||||
| 4. Round | 27/02/2022 | Herrera FC | - | Atlético Chiriquí | 1:2 |  |
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| 5. Round | 06/03/2022 | Veraguas United | - | Atlético Chiriquí | 1:3 |  |
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| 7. Round | 12/03/2022 | Atlético Chiriquí | - | Tauro FC | 1:0 |
Panama