| 2. Round | 10/08/2020 | Club Deportivo Ocotal | - | Managua FC | 5:0 |  |
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| 3. Round | 14/08/2020 | Club Deportivo Ocotal | - | Junior Managua | 3:1 | ||||
| 5. Round | 24/08/2020 | Club Deportivo Ocotal | - | Real Madriz | 1:1 |  |
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| 6. Round | 31/08/2020 | Juventus Managua | - | Club Deportivo Ocotal | 1:0 | ||||
| 7. Round | 07/09/2020 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 0:0 | ||||
| 8. Round | 13/09/2020 | CD Walter Ferretti | - | Club Deportivo Ocotal | 2:0 | |
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| 9. Round | 20/09/2020 | Club Deportivo Ocotal | - | Diriangén FC | 1:0 | |
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| 10. Round | 27/09/2020 | Club Deportivo Ocotal | - | Real Estelí FC | 0:1 | |
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| 12. Round | 18/10/2020 | Junior Managua | - | Club Deportivo Ocotal | 1:0 | ||||
| 13. Round | 26/10/2020 | Club Deportivo Ocotal | - | Chinandega | 1:2 | ||||
| 14. Round | 30/10/2020 | Real Madriz | - | Club Deportivo Ocotal | 0:1 | |
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| 15. Round | 01/11/2020 | Club Deportivo Ocotal | - | Juventus Managua | 0:0 | ||||
| 16. Round | 12/11/2020 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 2:0 | ||||
| 17. Round | 15/11/2020 | Club Deportivo Ocotal | - | CD Walter Ferretti | 2:0 | ||||
| 18. Round | 20/11/2020 | Diriangén FC | - | Club Deportivo Ocotal | 6:1 |
Honduras