1. Round | 18/07/2021 | Santa Fe | - | Deportivo Cali | 1:2 | ||||
3. Round | 04/08/2021 | Santa Fe | - | Atlético Nacional | 0:1 | ||||
4. Round | 08/08/2021 | Millonarios | - | Santa Fe | 0:1 | ||||
5. Round | 17/08/2021 | Santa Fe | - | La Equidad | 0:2 | ||||
7. Round | 30/08/2021 | Santa Fe | - | América de Cali | 1:1 | ||||
8. Round | 05/09/2021 | Independiente Medellín | - | Santa Fe | 0:0 | ||||
9. Round | 12/09/2021 | Santa Fe | - | Alianza Petrolera | 1:1 |