| 1. Round | 20/01/2022 | Honduras Progreso | - | Motagua | 2:1 |  |
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| 2. Round | 23/01/2022 | Honduras Progreso | - | Lobos UPNFM | 1:2 | ||||
| 3. Round | 06/02/2022 | Olimpia | - | Honduras Progreso | 3:0 | ||||
| 4. Round | 10/02/2022 | Real Sociedad | - | Honduras Progreso | 4:2 | ||||
| 5. Round | 13/02/2022 | Honduras Progreso | - | Marathón | 2:1 | ||||
| 6. Round | 20/02/2022 | Vida | - | Honduras Progreso | 0:2 | ||||
| 7. Round | 27/02/2022 | Real España | - | Honduras Progreso | 3:0 | |
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| 8. Round | 04/03/2022 | Honduras Progreso | - | Victoria | 2:1 | ||||
| 9. Round | 06/03/2022 | Platense | - | Honduras Progreso | 0:0 | ||||
| 10. Round | 13/03/2022 | Honduras Progreso | - | Olimpia | 1:3 | ||||
| 11. Round | 19/03/2022 | Lobos UPNFM | - | Honduras Progreso | 2:2 | ||||
| 12. Round | 03/04/2022 | Honduras Progreso | - | Real Sociedad | 0:1 | ||||
| 13. Round | 07/04/2022 | Marathón | - | Honduras Progreso | 1:1 | ||||
| 15. Round | 14/04/2022 | Victoria | - | Honduras Progreso | 2:2 | ||||
| 17. Round | 24/04/2022 | Honduras Progreso | - | Real España | 1:1 | ||||
| 18. Round | 01/05/2022 | Honduras Progreso | - | Platense | 3:1 |
Honduras