| 1. Round | 08/07/2022 | Deportivo Pereira | - | Alianza Petrolera | 1:2 | ||||
| 2. Round | 13/07/2022 | Alianza Petrolera | - | Unión Magdalena | 0:1 | ||||
| 3. Round | 17/07/2022 | Envigado FC | - | Alianza Petrolera | 2:2 | ||||
| 4. Round | 23/07/2022 | Alianza Petrolera | - | Atlético Bucaramanga | 3:1 | ||||
| 5. Round | 30/07/2022 | Jaguares de Córdoba | - | Alianza Petrolera | 2:1 |  |
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| 6. Round | 07/08/2022 | Alianza Petrolera | - | Atlético Nacional | 0:2 | |
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| 11. Round | 13/09/2022 | Águilas Doradas | - | Alianza Petrolera | 1:0 | ||||
| 12. Round | 17/09/2022 | Alianza Petrolera | - | La Equidad | 1:2 | |
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| 13. Round | 22/09/2022 | Patriotas FC | - | Alianza Petrolera | 0:0 | ||||
| 14. Round | 26/09/2022 | Alianza Petrolera | - | Atlético Junior | 0:1 | ||||
| 15. Round | 01/10/2022 | Independiente Medellín | - | Alianza Petrolera | 3:1 | ||||
| 16. Round | 11/10/2022 | Alianza Petrolera | - | Santa Fe | 4:0 | ||||
| 17. Round | 13/10/2022 | Deportes Tolima | - | Alianza Petrolera | 2:0 | ||||
| 18. Round | 18/10/2022 | Alianza Petrolera | - | América de Cali | 0:2 | ||||
| 19. Round | 24/10/2022 | Once Caldas | - | Alianza Petrolera | 1:1 | ||||
| 20. Round | 30/10/2022 | Alianza Petrolera | - | Millonarios | 2:4 |
Colombia