| 10. Round | 22/05/2021 | Energetik-BGU Minsk | - | FK Slutsk | 1:0 | ||||
| 18. Round | 30/07/2021 | Energetik-BGU Minsk | - | Rukh Brest | 0:2 | ||||
| 21. Round | 29/08/2021 | Neman Grodno | - | Energetik-BGU Minsk | 3:0 | ||||
| 17. Round | 22/09/2021 | Shakhter Soligorsk | - | Energetik-BGU Minsk | 2:0 | ||||
| 24. Round | 26/09/2021 | Energetik-BGU Minsk | - | FK Vitebsk | 2:2 | ||||
| 25. Round | 03/10/2021 | FK Slutsk | - | Energetik-BGU Minsk | 2:0 | ||||
| 26. Round | 17/10/2021 | Energetik-BGU Minsk | - | Dinamo Brest | 0:0 | ||||
| 27. Round | 23/10/2021 | FK Gomel | - | Energetik-BGU Minsk | 4:0 | ||||
| 28. Round | 06/11/2021 | Energetik-BGU Minsk | - | FK Minsk | 1:1 | ||||
| 29. Round | 20/11/2021 | Energetik-BGU Minsk | - | FK Slaviya Mozyr | 2:3 | ||||
| 30. Round | 28/11/2021 | FK Isloch Minsk | - | Energetik-BGU Minsk | 0:4 |
Belarus