| 1. Round | 01/08/2010 | Cercle Brugge | - | Sporting Charleroi | 1:1 | ||||
| 2. Round | 07/08/2010 | Sporting Charleroi | - | RSC Anderlecht | 0:0 | ||||
| 3. Round | 15/08/2010 | KRC Genk | - | Sporting Charleroi | 5:0 | ||||
| 10. Round | 02/10/2010 | SV Zulte Waregem | - | Sporting Charleroi | 1:1 | ||||
| 11. Round | 16/10/2010 | Sporting Charleroi | - | Sporting Lokeren | 1:2 | ||||
| 17. Round | 27/11/2010 | RSC Anderlecht | - | Sporting Charleroi | 4:1 | ||||
| 19. Round | 11/12/2010 | KAA Gent | - | Sporting Charleroi | 2:1 |  |
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| 20. Round | 18/12/2010 | KAS Eupen | - | Sporting Charleroi | 1:0 | ||||
| 22. Round | 29/12/2010 | Club Brugge KV | - | Sporting Charleroi | 5:0 |
Israel