2. Round | 01/08/2021 | Guadalupe | - | AD San Carlos | 1:1 | ||||
7. Round | 25/08/2021 | CS Cartaginés | - | Guadalupe | 0:1 | ||||
10. Round | 12/09/2021 | Guadalupe | - | LD Alajuelense | 2:4 | ||||
16. Round | 17/10/2021 | Guadalupe | - | Municipal Pérez Zeledón | 0:1 | ||||
17. Round | 23/10/2021 | Sporting FC | - | Guadalupe | 2:0 | ||||
18. Round | 27/10/2021 | Guadalupe | - | CS Cartaginés | 1:1 | ||||
19. Round | 30/10/2021 | Guadalupe | - | Jicaral | 2:0 | ||||
20. Round | 21/11/2021 | Municipal Grecia | - | Guadalupe | 0:0 | ||||
22. Round | 28/11/2021 | Guadalupe | - | Santos de Guápiles | 0:5 |