| 2. Round | 20/03/2021 | FK Minsk | - | Rukh Brest | 2:2 | ||||
| 5. Round | 18/04/2021 | Rukh Brest | - | FK Smorgon | 5:0 | ||||
| 12. Round | 13/06/2021 | Rukh Brest | - | Torpedo-BelAZ Zhodino | 3:0 |  |
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| 13. Round | 19/06/2021 | FK Vitebsk | - | Rukh Brest | 0:0 | ||||
| 14. Round | 27/06/2021 | Rukh Brest | - | FK Slutsk | 1:0 | ||||
| 15. Round | 04/07/2021 | Dinamo Brest | - | Rukh Brest | 1:1 |  |
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| 16. Round | 17/07/2021 | FK Gomel | - | Rukh Brest | 0:0 | |
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| 18. Round | 30/07/2021 | Energetik-BGU Minsk | - | Rukh Brest | 0:2 | ||||
| 22. Round | 12/09/2021 | FK Slaviya Mozyr | - | Rukh Brest | 1:1 | |
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| 24. Round | 25/09/2021 | Rukh Brest | - | BATE Borisov | 2:2 | |
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| 25. Round | 01/10/2021 | Neman Grodno | - | Rukh Brest | 0:1 | ||||
| 26. Round | 17/10/2021 | Rukh Brest | - | Dinamo Minsk | 1:3 | ||||
| 27. Round | 24/10/2021 | Torpedo-BelAZ Zhodino | - | Rukh Brest | 3:3 | ||||
| 28. Round | 05/11/2021 | Rukh Brest | - | FK Vitebsk | 2:0 | ||||
| 29. Round | 20/11/2021 | FK Slutsk | - | Rukh Brest | 3:0 |  |
Albania