| 1. Round | 19/01/2022 | Lobos UPNFM | - | Vida | 3:0 dec. | ||||
| 4. Round | 10/02/2022 | Vida | - | Olimpia | 0:3 | ||||
| 6. Round | 20/02/2022 | Vida | - | Honduras Progreso | 0:2 |  |
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| 8. Round | 03/03/2022 | Vida | - | Real Sociedad | 4:0 | ||||
| 9. Round | 06/03/2022 | Vida | - | Real España | 0:1 | ||||
| 10. Round | 12/03/2022 | Marathón | - | Vida | 1:1 | ||||
| 11. Round | 20/03/2022 | Vida | - | Motagua | 2:0 | ||||
| 12. Round | 03/04/2022 | Olimpia | - | Vida | 2:0 | ||||
| 13. Round | 07/04/2022 | Vida | - | Platense | 1:1 | ||||
| 14. Round | 10/04/2022 | Honduras Progreso | - | Vida | 3:1 | ||||
| 15. Round | 15/04/2022 | Real Sociedad | - | Vida | 4:1 | ||||
| 16. Round | 21/04/2022 | Vida | - | Lobos UPNFM | 4:2 | ||||
| 17. Round | 24/04/2022 | Vida | - | Victoria | 1:1 | ||||
| 18. Round | 01/05/2022 | Real España | - | Vida | 1:4 |  |
Honduras