| 5. Round | 21/08/2021 | SM Caen | - | AS Nancy Lorraine | 1:0 | ||||
| 6. Round | 28/08/2021 | AS Nancy Lorraine | - | AJ Auxerre | 1:4 | ||||
| 8. Round | 18/09/2021 | AS Nancy Lorraine | - | Havre AC | 1:1 | ||||
| 9. Round | 21/09/2021 | Grenoble Foot 38 | - | AS Nancy Lorraine | 4:1 | ||||
| 10. Round | 24/09/2021 | AS Nancy Lorraine | - | Amiens SC | 1:1 | ||||
| 12. Round | 16/10/2021 | AS Nancy Lorraine | - | EA Guingamp | 2:1 | ||||
| 14. Round | 30/10/2021 | AS Nancy Lorraine | - | FC Sochaux | 0:0 | ||||
| 15. Round | 06/11/2021 | Chamois Niortais | - | AS Nancy Lorraine | 1:3 | ||||
| 16. Round | 20/11/2021 | AS Nancy Lorraine | - | Rodez AF | 0:2 | ||||
| 17. Round | 03/12/2021 | US Quevilly-Rouen | - | AS Nancy Lorraine | 2:1 | ||||
| 18. Round | 11/12/2021 | Nîmes Olympique | - | AS Nancy Lorraine | 2:1 | ||||
| 19. Round | 21/12/2021 | AS Nancy Lorraine | - | Dijon FCO | 0:3 | ||||
| 20. Round | 19/01/2022 | Toulouse FC | - | AS Nancy Lorraine | 4:0 | ||||
| 27. Round | 05/03/2022 | AS Nancy Lorraine | - | Grenoble Foot 38 | 0:1 |  |
Portugal
Angola