| 1. Round | 19/07/2021 | Deportivo Pasto | - | Millonarios | 1:3 | ||||
| 2. Round | 22/07/2021 | Millonarios | - | Deportes Quindío | 2:1 | ||||
| 3. Round | 02/08/2021 | Once Caldas | - | Millonarios | 0:2 | ||||
| 4. Round | 08/08/2021 | Millonarios | - | Santa Fe | 0:1 |  |
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| 5. Round | 15/08/2021 | Deportivo Cali | - | Millonarios | 2:2 |  |
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| 7. Round | 29/08/2021 | Deportivo Pereira | - | Millonarios | 1:0 | ||||
| 8. Round | 07/09/2021 | Millonarios | - | Patriotas FC | 1:0 | ||||
| 9. Round | 12/09/2021 | Atlético Bucaramanga | - | Millonarios | 3:4 | |
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| 10. Round | 19/09/2021 | Millonarios | - | Atlético Huila | 3:1 |  |
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| 11. Round | 26/09/2021 | Jaguares de Córdoba | - | Millonarios | 4:3 | |
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| 14. Round | 18/10/2021 | Santa Fe | - | Millonarios | 0:2 | ||||
| 15. Round | 24/10/2021 | Millonarios | - | Atlético Junior | 4:1 | ||||
| 16. Round | 26/10/2021 | Envigado FC | - | Millonarios | 2:1 | ||||
| 17. Round | 31/10/2021 | Millonarios | - | La Equidad | 0:1 | ||||
| 18. Round | 07/11/2021 | Deportes Tolima | - | Millonarios | 3:2 | ||||
| 19. Round | 14/11/2021 | Millonarios | - | Alianza Petrolera | 1:1 | |
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| 20. Round | 21/11/2021 | Atlético Nacional | - | Millonarios | 1:3 |
Colombia