| 1. Round | 08/02/2022 | Cerrito | - | Danubio | 0:1 | ||||
| 2. Round | 15/02/2022 | Deportivo Maldonado | - | Danubio | 1:2 |  |
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| 3. Round | 20/02/2022 | Danubio | - | Rentistas | 0:1 | |
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| 4. Round | 26/02/2022 | Liverpool | - | Danubio | 0:1 | ||||
| 5. Round | 05/03/2022 | Danubio | - | Peñarol | 0:1 | |
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| 6. Round | 22/03/2022 | Montevideo City Torque | - | Danubio | 1:1 | ||||
| 7. Round | 02/04/2022 | Danubio | - | Montevideo Wanderers | 0:0 | ||||
| 8. Round | 09/04/2022 | Plaza Colonia | - | Danubio | 1:1 | ||||
| 9. Round | 15/04/2022 | Danubio | - | Boston River | 0:0 | |
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| 10. Round | 23/04/2022 | River Plate | - | Danubio | 0:0 | ||||
| 11. Round | 08/05/2022 | Danubio | - | Cerro Largo | 2:0 | |
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| 12. Round | 15/05/2022 | Fénix | - | Danubio | 0:0 | ||||
| 13. Round | 22/05/2022 | Danubio | - | Defensor Sporting | 1:2 | ||||
| 14. Round | 27/05/2022 | Albion | - | Danubio | 1:2 | ||||
| 15. Round | 05/06/2022 | Danubio | - | Nacional | 2:1 |
Uruguay