| 2. Round | 13/05/2021 | Inter Miami CF | - | CF Montréal | 0:2 | ||||
| 3. Round | 24/06/2021 | CF Montréal | - | D.C. United | 0:0 | ||||
| 3. Round | 27/06/2021 | Nashville SC | - | CF Montréal | 1:1 | ||||
| 4. Round | 08/07/2021 | CF Montréal | - | New York City FC | 2:1 | ||||
| 4. Round | 18/07/2021 | CF Montréal | - | FC Cincinnati | 5:4 | ||||
| 4. Round | 25/07/2021 | New England Revolution | - | CF Montréal | 2:1 | ||||
| 5. Round | 09/08/2021 | D.C. United | - | CF Montréal | 2:1 | ||||
| 5. Round | 15/08/2021 | CF Montréal | - | New York RB | 2:1 | ||||
| 5. Round | 19/08/2021 | FC Cincinnati | - | CF Montréal | 0:0 |  |
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| 5. Round | 22/08/2021 | Philadelphia Union | - | CF Montréal | 1:1 | ||||
| 5. Round | 28/08/2021 | CF Montréal | - | Toronto FC | 3:1 | ||||
| 6. Round | 16/09/2021 | Orlando City | - | CF Montréal | 2:4 | ||||
| 6. Round | 19/09/2021 | CF Montréal | - | Chicago Fire | 2:0 | ||||
| 7. Round | 16/10/2021 | CF Montréal | - | Philadelphia Union | 2:2 | ||||
| 7. Round | 21/10/2021 | Orlando City | - | CF Montréal | 1:1 | ||||
| 7. Round | 24/10/2021 | Toronto FC | - | CF Montréal | 1:1 | |
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| 7. Round | 30/10/2021 | New York RB | - | CF Montréal | 1:0 | ||||
| 8. Round | 03/11/2021 | CF Montréal | - | Houston Dynamo | 2:0 |
Argentina