| 3. Round | 07/02/2025 | Águilas Doradas | - | Santa Fe | 0:0 |  |
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| 4. Round | 13/02/2025 | Santa Fe | - | Atlético Nacional | 2:2 | |
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| 7. Round | 28/02/2025 | Envigado FC | - | Santa Fe | 1:7 | ||||
| 8. Round | 09/03/2025 | Santa Fe | - | Fortaleza FC | 2:0 | ||||
| 9. Round | 16/03/2025 | Once Caldas | - | Santa Fe | 0:1 | |
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| 6. Round | 19/03/2025 | Santa Fe | - | Atlético Bucaramanga | 1:1 | |
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| 10. Round | 23/03/2025 | Santa Fe | - | Millonarios | 3:2 | |
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| 11. Round | 30/03/2025 | Unión Magdalena | - | Santa Fe | 0:1 | |
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| 12. Round | 05/04/2025 | Santa Fe | - | Deportivo Pasto | 1:1 | ||||
| 13. Round | 11/04/2025 | La Equidad | - | Santa Fe | 2:1 | ||||
| 14. Round | 15/04/2025 | Santa Fe | - | Independiente Medellín | 1:2 | ||||
| 16. Round | 27/04/2025 | Santa Fe | - | Boyacá Chicó | 0:0 | ||||
| 18. Round | 11/05/2025 | Santa Fe | - | Atlético Junior | 2:1 | |
Argentina