| 2. Round | 17/09/2021 | Ionikos Nikea | - | Aris Saloniki | 1:0 | ||||
| 9. Round | 07/11/2021 | Volos NFC | - | Aris Saloniki | 1:2 | ||||
| 10. Round | 20/11/2021 | Aris Saloniki | - | PAS Giannina | 0:5 | ||||
| 12. Round | 05/12/2021 | Aris Saloniki | - | Asteras Tripolis | 1:0 | ||||
| 13. Round | 12/12/2021 | Olympiakos Piraeus | - | Aris Saloniki | 1:0 |  |
|||
| 14. Round | 16/12/2021 | OFI Heraklion | - | Aris Saloniki | 1:1 | |
|||
| 15. Round | 20/12/2021 | Aris Saloniki | - | Ionikos Nikea | 1:0 | ||||
| 16. Round | 05/01/2022 | Panathinaikos | - | Aris Saloniki | 2:0 | ||||
| 20. Round | 30/01/2022 | Panetolikos | - | Aris Saloniki | 0:2 | ||||
| 21. Round | 02/02/2022 | Aris Saloniki | - | AEK Athen | 2:1 |  |
|||
| 22. Round | 05/02/2022 | Aris Saloniki | - | Volos NFC | 0:2 | ||||
| 23. Round | 14/02/2022 | PAS Giannina | - | Aris Saloniki | 2:0 | ||||
| 24. Round | 20/02/2022 | Aris Saloniki | - | PAOK Saloniki | 0:0 | ||||
| 17. Round | 23/02/2022 | Aris Saloniki | - | Atromitos | 3:0 | ||||
| 26. Round | 06/03/2022 | Aris Saloniki | - | Olympiakos Piraeus | 2:1 |
Austria