| 1. Round | 19/01/2025 | Plaza Amador | - | Sporting San Miguelito | 0:1 |  |
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| 2. Round | 25/01/2025 | Sporting San Miguelito | - | Potros del Este | 0:0 | ||||
| 4. Round | 08/02/2025 | Árabe Unido | - | Sporting San Miguelito | 2:1 | ||||
| 5. Round | 15/02/2025 | Sporting San Miguelito | - | Tauro FC | 1:0 | |
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| 3. Round | 21/02/2025 | Alianza | - | Sporting San Miguelito | 1:2 |  |
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| 7. Round | 27/02/2025 | Sporting San Miguelito | - | Veraguas United | 2:2 | ||||
| 8. Round | 09/03/2025 | Independiente de La Chorrera | - | Sporting San Miguelito | 4:0 | ||||
| 9. Round | 15/03/2025 | Sporting San Miguelito | - | San Francisco FC | 0:1 | ||||
| 10. Round | 22/03/2025 | UD Universitario | - | Sporting San Miguelito | 1:0 | ||||
| 11. Round | 31/03/2025 | UMECIT | - | Sporting San Miguelito | 0:0 | |
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| 12. Round | 07/04/2025 | Tauro FC | - | Sporting San Miguelito | 0:1 | |
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| 13. Round | 14/04/2025 | Sporting San Miguelito | - | Árabe Unido | 1:0 | ||||
| 14. Round | 29/04/2025 | Potros del Este | - | Sporting San Miguelito | 3:3 | ||||
| 15. Round | 04/05/2025 | Sporting San Miguelito | - | Alianza | 2:0 | ||||
| 16. Round | 11/05/2025 | Sporting San Miguelito | - | Plaza Amador | 0:1 |
Panama