| 1. Round | 03/07/2023 | Santos Laguna | - | Gallos Blancos | 0:2 | ||||
| 2. Round | 08/07/2023 | Puebla FC | - | Santos Laguna | 2:3 | ||||
| 3. Round | 14/07/2023 | Santos Laguna | - | Atlas Guadalajara | 0:0 | ||||
| 4. Round | 21/08/2023 | Cruz Azul | - | Santos Laguna | 2:2 | ||||
| 6. Round | 27/08/2023 | Santos Laguna | - | Deportivo Guadalajara | 2:1 | ||||
| 5. Round | 31/08/2023 | UANL Tigres | - | Santos Laguna | 3:2 |  |
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| 7. Round | 03/09/2023 | Santos Laguna | - | Pumas UNAM | 2:1 |  |
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| 8. Round | 19/09/2023 | CF Pachuca | - | Santos Laguna | 3:2 | ||||
| 9. Round | 25/09/2023 | Santos Laguna | - | Club Necaxa | 2:5 | ||||
| 11. Round | 05/10/2023 | Santos Laguna | - | Club Tijuana | 2:1 | ||||
| 12. Round | 09/10/2023 | Santos Laguna | - | Club León | 0:2 | ||||
| 13. Round | 22/10/2023 | CF América | - | Santos Laguna | 4:3 | |
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| 14. Round | 30/10/2023 | Santos Laguna | - | FC Juárez | 5:1 | ||||
| 15. Round | 02/11/2023 | Mazatlán FC | - | Santos Laguna | 3:1 | ||||
| 16. Round | 06/11/2023 | Santos Laguna | - | Deportivo Toluca | 3:1 | ||||
| 10. Round | 09/11/2023 | CF Monterrey | - | Santos Laguna | 3:0 | ||||
| 17. Round | 11/11/2023 | Atlético San Luis | - | Santos Laguna | 0:2 |
Colombia