| 1. Round | 27/08/2005 | Skoda Xanthi | - | PAOK Saloniki | 1:0 | ||||
| 2. Round | 11/09/2005 | OFI Heraklion | - | Skoda Xanthi | 1:1 | ||||
| 3. Round | 18/09/2005 | Skoda Xanthi | - | Apollon Kalamarias | 2:0 | ||||
| 4. Round | 25/09/2005 | Skoda Xanthi | - | Levadiakos | 1:0 | ||||
| 5. Round | 03/10/2005 | Atromitos | - | Skoda Xanthi | 0:1 |  |
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| 6. Round | 17/10/2005 | Skoda Xanthi | - | Iraklis Saloniki | 4:1 | ||||
| 7. Round | 23/10/2005 | AO Egaleo | - | Skoda Xanthi | 3:2 | ||||
| 8. Round | 30/10/2005 | Skoda Xanthi | - | AE Lárissa | 1:0 | ||||
| 9. Round | 06/11/2005 | Olympiakos Piraeus | - | Skoda Xanthi | 2:0 | ||||
| 10. Round | 19/11/2005 | Skoda Xanthi | - | Ionikos Nikea | 1:1 | ||||
| 11. Round | 26/11/2005 | Panathinaikos | - | Skoda Xanthi | 2:1 | ||||
| 12. Round | 05/12/2005 | Panionios GSS | - | Skoda Xanthi | 0:2 |  |
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| 13. Round | 11/12/2005 | Skoda Xanthi | - | GS Kallithea | 2:2 | ||||
| 14. Round | 19/12/2005 | Akratitos Liosion | - | Skoda Xanthi | 2:0 | |
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| 15. Round | 08/01/2006 | Skoda Xanthi | - | AEK Athen | 0:0 | ||||
| 16. Round | 15/01/2006 | PAOK Saloniki | - | Skoda Xanthi | 1:0 |
Brazil