| 1. Round | 31/07/2022 | Cerro Largo | - | Montevideo City Torque | 1:2 |  |
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| 2. Round | 06/08/2022 | Cerro Largo | - | Montevideo Wanderers | 1:1 | ||||
| 3. Round | 12/08/2022 | Plaza Colonia | - | Cerro Largo | 2:0 | ||||
| 5. Round | 29/08/2022 | Cerro Largo | - | River Plate | 0:5 | ||||
| 4. Round | 04/09/2022 | Cerro Largo | - | Boston River | 1:1 | ||||
| 7. Round | 11/09/2022 | Cerro Largo | - | Fénix | 1:0 | |
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| 8. Round | 16/09/2022 | Defensor Sporting | - | Cerro Largo | 0:1 | ||||
| 9. Round | 18/09/2022 | Cerro Largo | - | Albion | 1:2 | |
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| 10. Round | 25/09/2022 | Nacional | - | Cerro Largo | 1:1 |  |
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| 11. Round | 30/09/2022 | Cerro Largo | - | Danubio | 1:0 | ||||
| 12. Round | 07/10/2022 | Deportivo Maldonado | - | Cerro Largo | 0:1 | ||||
| 13. Round | 11/10/2022 | Cerro Largo | - | Rentistas | 2:1 | ||||
| 14. Round | 16/10/2022 | Liverpool | - | Cerro Largo | 1:0 | ||||
| 15. Round | 22/10/2022 | Cerro Largo | - | Peñarol | 0:2 | |
Uruguay