| 1. Round | 13/08/2021 | SD Huesca | - | SD Eibar | 2:0 | ||||
| 2. Round | 22/08/2021 | SD Huesca | - | FC Cartagena | 2:0 | ||||
| 3. Round | 27/08/2021 | UD Las Palmas | - | SD Huesca | 2:1 | ||||
| 4. Round | 06/09/2021 | SD Huesca | - | Real Oviedo | 1:2 | ||||
| 8. Round | 02/10/2021 | SD Huesca | - | CD Tenerife | 1:2 | ||||
| 11. Round | 19/10/2021 | SD Huesca | - | Málaga CF | 0:0 | ||||
| 12. Round | 24/10/2021 | Burgos CF | - | SD Huesca | 3:1 | ||||
| 22. Round | 02/01/2022 | SD Huesca | - | Girona FC | 0:1 | ||||
| 23. Round | 08/01/2022 | FC Cartagena | - | SD Huesca | 0:3 | ||||
| 24. Round | 23/01/2022 | SD Huesca | - | SD Ponferradina | 1:2 | ||||
| 25. Round | 29/01/2022 | SD Eibar | - | SD Huesca | 2:1 | ||||
| 28. Round | 20/02/2022 | SD Huesca | - | CD Lugo | 1:0 | ||||
| 29. Round | 26/02/2022 | UD Ibiza | - | SD Huesca | 2:1 | ||||
| 39. Round | 07/05/2022 | SD Huesca | - | Sporting Gijón | 1:1 | ||||
| 40. Round | 14/05/2022 | SD Amorebieta | - | SD Huesca | 1:0 |
France