2. Round | 21/08/2021 | Birkirkara FC | - | Hamrun Spartans | 2:1 | ||||
3. Round | 12/09/2021 | Balzan FC | - | Birkirkara FC | 1:2 | ||||
4. Round | 19/09/2021 | Birkirkara FC | - | Floriana FC | 1:1 | ||||
6. Round | 16/10/2021 | Birkirkara FC | - | Gudja United | 2:0 | ||||
7. Round | 24/10/2021 | Sirens FC | - | Birkirkara FC | 3:2 | ||||
8. Round | 30/10/2021 | Birkirkara FC | - | Hibernians FC | 1:1 | ||||
10. Round | 27/11/2021 | Birkirkara FC | - | Sliema Wanderers | 2:0 | ||||
11. Round | 04/12/2021 | Valletta FC | - | Birkirkara FC | 0:0 | ||||
12. Round | 12/12/2021 | Birkirkara FC | - | Mosta FC | 2:2 | ||||
14. Round | 19/01/2022 | Birkirkara FC | - | Balzan FC | 3:2 | ||||
16. Round | 30/01/2022 | Birkirkara FC | - | Gżira United | 1:0 | ||||
18. Round | 13/02/2022 | Birkirkara FC | - | Sirens FC | 1:1 | ||||
19. Round | 19/02/2022 | Hibernians FC | - | Birkirkara FC | 2:3 | ||||
22. Round | 12/03/2022 | Birkirkara FC | - | Valletta FC | 1:1 |