| 1. Round | 12/08/2000 | KSK Beveren | - | RSC Charleroi | 1:2 |  |
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| 2. Round | 19/08/2000 | RSC Charleroi | - | KRC Harelbeke | 5:0 | |
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| 3. Round | 27/08/2000 | RSC Charleroi | - | Royal Antwerp FC | 1:0 | ||||
| 6. Round | 17/09/2000 | KRC Genk | - | RSC Charleroi | 2:1 | ||||
| 7. Round | 23/09/2000 | RSC Charleroi | - | KAA Gent | 4:3 | ||||
| 8. Round | 29/09/2000 | Excelsior Mouscron | - | RSC Charleroi | 3:0 | ||||
| 9. Round | 14/10/2000 | RSC Charleroi | - | Sporting Lokeren | 1:0 | ||||
| 10. Round | 20/10/2000 | Standard Liège | - | RSC Charleroi | 4:0 | |
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| 11. Round | 28/10/2000 | RSC Charleroi | - | RAA La Louviére | 2:1 | |
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| 12. Round | 11/11/2000 | Germinal Beerschot | - | RSC Charleroi | 0:2 | ||||
| 13. Round | 17/11/2000 | RSC Charleroi | - | Club Brugge KV | 0:4 | ||||
| 14. Round | 25/11/2000 | KV Mechelen | - | RSC Charleroi | 4:3 |
Belgium