| 12. Round | 05/12/2021 | AEL Limassol | - | Omonia Nikosia | 0:1 | ||||
| 13. Round | 13/12/2021 | Omonia Nikosia | - | AEK Larnaca | 1:1 | ||||
| 14. Round | 19/12/2021 | Doxa Katokopias | - | Omonia Nikosia | 2:1 | ||||
| 1. Round | 22/12/2021 | Omonia Nikosia | - | AEL Limassol | 1:0 | ||||
| 11. Round | 26/12/2021 | APOEL Nikosia | - | Omonia Nikosia | 4:2 | ||||
| 17. Round | 16/01/2022 | Apollon Limassol | - | Omonia Nikosia | 2:0 | ||||
| 18. Round | 24/01/2022 | Omonia Nikosia | - | PAEEK | 2:1 | ||||
| 19. Round | 29/01/2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 |  |
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| 20. Round | 07/02/2022 | Omonia Nikosia | - | Ethnikos Achna | 0:2 | ||||
| 21. Round | 16/02/2022 | Aris Limassol | - | Omonia Nikosia | 0:2 |  |
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| 22. Round | 25/02/2022 | Omonia Nikosia | - | APOEL Nikosia | 2:4 | |
France
