| 1. Round | 13/08/2016 | FC Metz | - | Lille OSC | 3:2 | ||||
| 2. Round | 20/08/2016 | Lille OSC | - | Dijon FCO | 1:0 | ||||
| 3. Round | 27/08/2016 | OGC Nice | - | Lille OSC | 1:1 | ||||
| 4. Round | 10/09/2016 | Lille OSC | - | AS Monaco | 1:4 |  |
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| 6. Round | 20/09/2016 | Lille OSC | - | Toulouse FC | 1:2 | |
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| 7. Round | 25/09/2016 | AS Saint-Étienne | - | Lille OSC | 3:1 | ||||
| 8. Round | 01/10/2016 | Lille OSC | - | AS Nancy Lorraine | 1:0 | |
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| 22. Round | 28/01/2017 | Olympique Lyonnais | - | Lille OSC | 1:2 | |
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| 24. Round | 07/02/2017 | Paris Saint-Germain | - | Lille OSC | 2:1 | ||||
| 25. Round | 11/02/2017 | Lille OSC | - | Angers SCO | 1:2 | ||||
| 26. Round | 18/02/2017 | SM Caen | - | Lille OSC | 0:1 | ||||
| 27. Round | 25/02/2017 | Lille OSC | - | Girondins Bordeaux | 2:3 | ||||
| 28. Round | 05/03/2017 | Toulouse FC | - | Lille OSC | 1:1 |
France
