1. Round | 08/08/2021 | Atlético Chiriquí | - | San Francisco FC | 1:1 | ||||
2. Round | 14/08/2021 | San Francisco FC | - | UD Universitario | 0:1 | ||||
3. Round | 22/08/2021 | Independiente de La Chorrera | - | San Francisco FC | 2:0 | ||||
4. Round | 28/08/2021 | San Francisco FC | - | Herrera FC | 1:3 | ||||
8. Round | 26/09/2021 | Deportivo del Este | - | San Francisco FC | 0:0 |