| 1. Round | 22/08/2021 | TS Galaxy | - | Kaizer Chiefs | 0:0 | ||||
| 2. Round | 25/08/2021 | Kaizer Chiefs | - | Baroka FC | 2:1 | ||||
| 3. Round | 12/09/2021 | Mamelodi Sundowns | - | Kaizer Chiefs | 2:0 | ||||
| 4. Round | 18/09/2021 | Kaizer Chiefs | - | Royal AM | 1:4 | ||||
| 5. Round | 26/09/2021 | Marumo Gallants | - | Kaizer Chiefs | 0:0 | ||||
| 6. Round | 02/10/2021 | AmaZulu FC | - | Kaizer Chiefs | 1:1 | ||||
| 7. Round | 16/10/2021 | Kaizer Chiefs | - | Chippa United | 4:0 | ||||
| 8. Round | 24/10/2021 | SuperSport United | - | Kaizer Chiefs | 1:2 | ||||
| 9. Round | 02/11/2021 | Kaizer Chiefs | - | Stellenbosch FC | 0:1 | ||||
| 10. Round | 06/11/2021 | Kaizer Chiefs | - | Orlando Pirates | 2:1 | ||||
| 11. Round | 21/11/2021 | Maritzburg United | - | Kaizer Chiefs | 0:1 | ||||
| 19. Round | 24/11/2021 | Kaizer Chiefs | - | AmaZulu FC | 1:1 | ||||
| 12. Round | 28/11/2021 | Moroka Swallows | - | Kaizer Chiefs | 1:3 | ||||
| 15. Round | 12/12/2021 | Kaizer Chiefs | - | Sekhukhune United | 2:0 | ||||
| 18. Round | 15/02/2022 | Cape Town City FC | - | Kaizer Chiefs | 0:0 |  |
|||
| 20. Round | 26/02/2022 | Baroka FC | - | Kaizer Chiefs | 0:1 | ||||
| 21. Round | 05/03/2022 | Orlando Pirates | - | Kaizer Chiefs | 1:2 |  |
|||
| 22. Round | 19/03/2022 | Kaizer Chiefs | - | Golden Arrows | 0:1 |
South Africa