| 5. Round | 14/08/2021 | AD San Carlos | - | Jicaral | 0:0 |  |
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| 7. Round | 25/08/2021 | Sporting FC | - | AD San Carlos | 0:0 | ||||
| 9. Round | 08/09/2021 | Santos de Guápiles | - | AD San Carlos | 2:2 | ||||
| 10. Round | 13/09/2021 | AD San Carlos | - | Deportivo Saprissa | 1:0 | ||||
| 11. Round | 15/09/2021 | Municipal Grecia | - | AD San Carlos | 3:2 | |
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| 12. Round | 18/09/2021 | LD Alajuelense | - | AD San Carlos | 2:2 | |
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| 13. Round | 26/09/2021 | AD San Carlos | - | Guadalupe | 4:2 | ||||
| 14. Round | 03/10/2021 | Municipal Pérez Zeledón | - | AD San Carlos | 1:1 | ||||
| 15. Round | 13/10/2021 | AD San Carlos | - | CS Cartaginés | 0:1 | ||||
| 16. Round | 17/10/2021 | Jicaral | - | AD San Carlos | 0:4 | ||||
| 17. Round | 23/10/2021 | AD San Carlos | - | CS Herediano | 0:0 | ||||
| 18. Round | 28/10/2021 | AD San Carlos | - | Sporting FC | 3:1 | ||||
| 19. Round | 01/11/2021 | AD Guanacasteca | - | AD San Carlos | 0:1 | ||||
| 21. Round | 24/11/2021 | Deportivo Saprissa | - | AD San Carlos | 3:0 | ||||
| 22. Round | 28/11/2021 | AD San Carlos | - | Municipal Grecia | 1:3 |
Costa Rica