| 1. Round | 21/07/2018 | FK Senica | - | Spartak Trnava | 1:0 | ||||
| 2. Round | 28/07/2018 | Spartak Trnava | - | Zlaté Moravce | 1:0 | ||||
| 3. Round | 04/08/2018 | FK Železiarne Podbrezová | - | Spartak Trnava | 1:0 | ||||
| 4. Round | 11/08/2018 | Spartak Trnava | - | MFK Zemplín Michalovce | 3:0 | ||||
| 5. Round | 18/08/2018 | FC Nitra | - | Spartak Trnava | 0:0 | ||||
| 7. Round | 02/09/2018 | AS Trenčín | - | Spartak Trnava | 1:0 | ||||
| 9. Round | 23/09/2018 | FC DAC 1904 | - | Spartak Trnava | 3:2 | ||||
| 10. Round | 29/09/2018 | Spartak Trnava | - | Slovan Bratislava | 1:2 | ||||
| 11. Round | 07/10/2018 | Spartak Trnava | - | ŠKF Sereď | 2:1 | ||||
| 12. Round | 20/10/2018 | Spartak Trnava | - | FK Senica | 4:1 | ||||
| 13. Round | 28/10/2018 | Zlaté Moravce | - | Spartak Trnava | 1:1 | ||||
| 14. Round | 03/11/2018 | Spartak Trnava | - | FK Železiarne Podbrezová | 2:0 | ||||
| 16. Round | 24/11/2018 | Spartak Trnava | - | FC Nitra | 2:3 | ||||
| 17. Round | 02/12/2018 | MFK Ružomberok | - | Spartak Trnava | 3:1 | ||||
| 18. Round | 08/12/2018 | Spartak Trnava | - | AS Trenčín | 3:1 |
Slovakia